TSC1

TSC1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	5EJC, 4Z6Y
معین‌کننده‌ها
نام‌های دیگر	TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1
شناسه‌های بیرونی	OMIM: 605284 MGI: 1929183 HomoloGene: 314 GeneCards: TSC1
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	28,581,179 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• chaperone binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • protein N-terminus binding; • Hsp70 protein binding; • ATPase inhibitor activity; • Hsp90 protein binding; • GTPase activating protein binding;
ترکیبات سلولی	• سیتوپلاسم; • cell cortex; • growth cone; • intracellular membrane-bounded organelle; • پای‌لایه; • membrane; • ریزرشته; • TSC1-TSC2 complex; • اسکلت سلولی; • سیتوزول; • هسته یاخته; • perinuclear region of cytoplasm; • lipid droplet; • پوسته یاخته; • cell projection; • GO:0009327 protein-containing complex; • chaperone complex; • GO:0097483، GO:0097481 postsynaptic density;
فرایند زیستی	• rRNA export from nucleus; • regulation of cell cycle; • neural tube closure; • cerebral cortex development; • memory T cell differentiation; • regulation of protein kinase activity; • positive regulation of focal adhesion assembly; • myelination; • GO:1903105 negative regulation of insulin receptor signaling pathway; • synapse organization; • regulation of translation; • hippocampus development; • regulation of phosphoprotein phosphatase activity; • cell-matrix adhesion; • potassium ion transport; • adaptive immune response; • protein heterooligomerization; • kidney development; • جنین‌شناسی دستگاه عصبی مرکزی; • cell projection organization; • GO:0032861، GO:0032862، GO:0032856 activation of GTPase activity; • regulation of focal adhesion assembly; • glucose import; • regulation of cell-matrix adhesion; • negative regulation of cell size; • response to insulin; • cardiac muscle cell differentiation; • negative regulation of translation; • negative regulation of cell population proliferation; • cellular response to oxygen-glucose deprivation; • adult locomotory behavior; • negative regulation of TOR signaling; • regulation of neuron death; • negative regulation of macroautophagy; • negative regulation of neuron projection development; • positive regulation of macroautophagy; • GO:0034259 negative regulation of GTPase activity; • regulation of stress fiber assembly; • positive regulation of stress fiber assembly; • negative regulation of oxidative stress-induced neuron death; • negative regulation of ATP-dependent activity; • protein stabilization;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	7248
	64930
	ENSG00000165699
	ENSMUSG00000026812
	Q92574
	Q9EP53
	NM_000368، NM_001008567، NM_001162426، NM_001162427، XM_005272211، XM_006717271، XM_017015096، XM_017015097، XM_017015098، XM_017015100، XM_017015101، NM_001362177 XM_011518979، NM_000368، NM_001008567، NM_001162426، NM_001162427، XM_005272211، XM_006717271، XM_017015096، XM_017015097، XM_017015098، XM_017015100، XM_017015101، NM_001362177
	NM_001289575، NM_001289576، XM_006498220، XM_006498221، XM_006498222، XM_006498223، XM_011239142، XM_011239143، XM_011239144، XM_030251935، XM_030251936، XM_036162446 NM_022887، NM_001289575، NM_001289576، XM_006498220، XM_006498221، XM_006498222، XM_006498223، XM_011239142، XM_011239143، XM_011239144، XM_030251935، XM_030251936، XM_036162446
	NP_001155898، NP_001155899، XP_005272268، XP_006717334، XP_011517281، XP_016870585، XP_016870586، XP_016870587، XP_016870589، XP_016870590، NP_001349106 NP_000359، NP_001155898، NP_001155899، XP_005272268، XP_006717334، XP_011517281، XP_016870585، XP_016870586، XP_016870587، XP_016870589، XP_016870590، NP_001349106
	NP_001276505، NP_075025، XP_006498283، XP_006498284، XP_006498285، XP_006498286، XP_011237444، XP_011237445، XP_011237446، XP_030107795، XP_030107796، XP_036018339 NP_001276504، NP_001276505، NP_075025، XP_006498283، XP_006498284، XP_006498285، XP_006498286، XP_011237444، XP_011237445، XP_011237446، XP_030107795، XP_030107796، XP_036018339
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

کمپلکس ۱ توبروز اسکلروزیس (انگلیسی: Tuberous Sclerosis Complex 1) که با نام هامارتین هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «TSC1» کُدگذاری می‌شود.^[۴]

این پروتئین همچون مولکول کمکی شپرون عمل می‌کند که فعالیت ای‌تی‌پی‌ایز پروتئین گرماشوک «Hsp90» را مهار و چرخهٔ شپرون آنرا کوتاه‌تر می‌کند. به نظر می‌رسد که ژن «TSC1»، یک ژن سرکوب‌گر تومور است.

اهمیت بالینی

نقص در ژن «TSC1» ممکن است سبب بروز توبروز اسکلروزیس گردد. همچنین، پروتئین حاصله در محافظت از یاخته‌های عصبی در ناحیهٔ CA3 هیپوکامپ در برابر سکته مغزی نقش دارد.^[۵]

تعامل مولکولی-شیمیایی

این پروتئین با مولکول‌های زیر، تعامل پروتئین-پروتئین دارد:

Hsp70^[۶]
PLK1^[۷]
TSC2^[۸]^[۷]^[۹]^[۱۰]^[۱۱]^[۱۲]^[۱۳]^[۱۴]^[۱۵]^[۱۶]^[۱۷]^[۱۸]^[۱۹]^[۲۰]^[۲۱]^[۲۲]^[۲۳]^[۲۴]^[۲۵]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026812 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TSC1 tuberous sclerosis 1".
↑ Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM (March 2013). "Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy". Nature Medicine. 19 (3): 351–7. doi:10.1038/nm.3097. PMC 3744134. PMID 23435171.
↑ Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M (December 2017). "Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients". The EMBO Journal. 36 (24): 3650–3665. doi:10.15252/embj.201796700. PMC 5730846. PMID 29127155.
↑ ^۷٫۰ ^۷٫۱ Astrinidis A, Senapedis W, Henske EP (January 2006). "Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner". Human Molecular Genetics. 15 (2): 287–97. doi:10.1093/hmg/ddi444. PMID 16339216.
↑ Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ (September 2002). "Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin". The Journal of Biological Chemistry. 277 (38): 35364–70. doi:10.1074/jbc.M205838200. PMID 12167664.
↑ Hodges AK, Li S, Maynard J, Parry L, Braverman R, Cheadle JP, DeClue JE, Sampson JR (December 2001). "Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin". Human Molecular Genetics. 10 (25): 2899–905. doi:10.1093/hmg/10.25.2899. PMID 11741833.
↑ Aicher LD, Campbell JS, Yeung RS (June 2001). "Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis". The Journal of Biological Chemistry. 276 (24): 21017–21. doi:10.1074/jbc.C100136200. PMID 11290735.
↑ van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P (June 1998). "Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products". Human Molecular Genetics. 7 (6): 1053–7. doi:10.1093/hmg/7.6.1053. PMID 9580671.
↑ Nellist M, Goedbloed MA, de Winter C, Verhaaf B, Jankie A, Reuser AJ, van den Ouweland AM, van der Sluijs P, Halley DJ (October 2002). "Identification and characterization of the interaction between tuberin and 14-3-3zeta". The Journal of Biological Chemistry. 277 (42): 39417–24. doi:10.1074/jbc.M204802200. PMID 12176984.
↑ Li Y, Inoki K, Guan KL (September 2004). "Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity". Molecular and Cellular Biology. 24 (18): 7965–75. doi:10.1128/MCB.24.18.7965-7975.2004. PMC 515062. PMID 15340059.
↑ Mak BC, Takemaru K, Kenerson HL, Moon RT, Yeung RS (February 2003). "The tuberin-hamartin complex negatively regulates beta-catenin signaling activity". The Journal of Biological Chemistry. 278 (8): 5947–51. doi:10.1074/jbc.C200473200. PMID 12511557.
↑ Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (April 2005). "Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis". Cell. 121 (2): 179–93. doi:10.1016/j.cell.2005.02.031. PMID 15851026. S2CID 18663447.
↑ Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL (April 2006). "Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning". The Journal of Cell Biology. 173 (2): 279–89. doi:10.1083/jcb.200507119. PMC 2063818. PMID 16636147.
↑ Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J (December 2006). "Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway". The Journal of Biological Chemistry. 281 (52): 40242–51. doi:10.1074/jbc.M608116200. PMID 17077083.
↑ Inoki K, Zhu T, Guan KL (November 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. 115 (5): 577–90. doi:10.1016/S0092-8674(03)00929-2. PMID 14651849. S2CID 18173817.
↑ Nellist M, Burgers PC, van den Ouweland AM, Halley DJ, Luider TM (August 2005). "Phosphorylation and binding partner analysis of the TSC1-TSC2 complex". Biochemical and Biophysical Research Communications. 333 (3): 818–26. doi:10.1016/j.bbrc.2005.05.175. PMID 15963462.
↑ Goncharova EA, Goncharov DA, Spaits M, Noonan DJ, Talovskaya E, Eszterhas A, Krymskaya VP (May 2006). "Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2". American Journal of Respiratory Cell and Molecular Biology. 34 (5): 561–72. doi:10.1165/rcmb.2005-0300OC. PMC 2644221. PMID 16424383.
↑ Astrinidis A, Senapedis W, Coleman TR, Henske EP (December 2003). "Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B". The Journal of Biological Chemistry. 278 (51): 51372–9. doi:10.1074/jbc.M303956200. PMID 14551205.
↑ Nellist M, Verhaaf B, Goedbloed MA, Reuser AJ, van den Ouweland AM, Halley DJ (December 2001). "TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex". Human Molecular Genetics. 10 (25): 2889–98. doi:10.1093/hmg/10.25.2889. PMID 11741832.
↑ Benvenuto G, Li S, Brown SJ, Braverman R, Vass WC, Cheadle JP, Halley DJ, Sampson JR, Wienecke R, DeClue JE (December 2000). "The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination". Oncogene. 19 (54): 6306–16. doi:10.1038/sj.onc.1204009. PMID 11175345.
↑ Murthy V, Haddad LA, Smith N, Pinney D, Tyszkowski R, Brown D, Ramesh V (May 2000). "Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney". American Journal of Physiology. Renal Physiology. 278 (5): F737–46. doi:10.1152/ajprenal.2000.278.5.F737. PMID 10807585.
↑ Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G, Hengstschläger M (July 2000). "The TSC1 gene product, hamartin, negatively regulates cell proliferation". Human Molecular Genetics. 9 (12): 1721–7. doi:10.1093/hmg/9.12.1721. PMID 10915759.

مشارکت‌کنندگان ویکی‌پدیا. «TSC1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۹ مارس ۲۰۲۱.

برای مطالعهٔ بیشتر

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Ramesh V (June 2003). "Aspects of tuberous sclerosis complex (TSC) protein function in the brain". Biochemical Society Transactions. 31 (Pt 3): 579–83. doi:10.1042/BST0310579. PMID 12773159.
Knowles MA, Hornigold N, Pitt E (June 2003). "Tuberous sclerosis complex (TSC) gene involvement in sporadic tumours". Biochemical Society Transactions. 31 (Pt 3): 597–602. doi:10.1042/BST0310597. PMID 12773163.
Ellisen LW (November 2005). "Growth control under stress: mTOR regulation through the REDD1-TSC pathway". Cell Cycle. 4 (11): 1500–02. doi:10.4161/cc.4.11.2139. PMID 16258273.
Jozwiak J, Jozwiak S (March 2007). "Giant cells: contradiction to two-hit model of tuber formation?". Cellular and Molecular Neurobiology. 27 (2): 251–61. doi:10.1007/s10571-006-9106-0. PMID 16897363. S2CID 31624726.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP, Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ (August 1997). "Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34". Science. 277 (5327): 805–8. doi:10.1126/science.277.5327.805. PMID 9242607.
Jones AC, Daniells CE, Snell RG, Tachataki M, Idziaszczyk SA, Krawczak M, Sampson JR, Cheadle JP (November 1997). "Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis". Human Molecular Genetics. 6 (12): 2155–61. doi:10.1093/hmg/6.12.2155. PMID 9328481.
van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P (June 1998). "Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products". Human Molecular Genetics. 7 (6): 1053–7. doi:10.1093/hmg/7.6.1053. PMID 9580671.
Plank TL, Yeung RS, Henske EP (November 1998). "Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles". Cancer Research. 58 (21): 4766–70. PMID 9809973.
Kwiatkowska J, Jozwiak S, Hall F, Henske EP, Haines JL, McNamara P, Braiser J, Wigowska-Sowinska J, Kasprzyk-Obara J, Short MP, Kwiatkowski DJ (July 1998). "Comprehensive mutational analysis of the TSC1 gene: observations on frequency of mutation, associated features, and nonpenetrance". Annals of Human Genetics. 62 (Pt 4): 277–85. doi:10.1046/j.1469-1809.1998.6240277.x. PMID 9924605. S2CID 12987381.
van Slegtenhorst M, Verhoef S, Tempelaars A, Bakker L, Wang Q, Wessels M, Bakker R, Nellist M, Lindhout D, Halley D, van den Ouweland A (April 1999). "Mutational spectrum of the TSC1 gene in a cohort of 225 tuberous sclerosis complex patients: no evidence for genotype-phenotype correlation". Journal of Medical Genetics. 36 (4): 285–9. doi:10.1136/jmg.36.4.285 (inactive 2021-01-13). PMC 1734341. PMID 10227394.{{cite journal}}: CS1 maint: DOI inactive as of ژانویه 2021 (link)
Niida Y, Lawrence-Smith N, Banwell A, Hammer E, Lewis J, Beauchamp RL, Sims K, Ramesh V, Ozelius L (2000). "Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis". Human Mutation. 14 (5): 412–22. doi:10.1002/(SICI)1098-1004(199911)14:5<412::AID-HUMU7>3.0.CO;2-K. PMID 10533067.
Zhang H, Nanba E, Yamamoto T, Ninomiya H, Ohno K, Mizuguchi M, Takeshita K (2000). "Mutational analysis of TSC1 and TSC2 genes in Japanese patients with tuberous sclerosis complex". Journal of Human Genetics. 44 (6): 391–6. doi:10.1007/s100380050185. PMID 10570911.
Nellist M, van Slegtenhorst MA, Goedbloed M, van den Ouweland AM, Halley DJ, van der Sluijs P (December 1999). "Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin". The Journal of Biological Chemistry. 274 (50): 35647–52. doi:10.1074/jbc.274.50.35647. PMID 10585443.
Yamashita Y, Ono J, Okada S, Wataya-Kaneda M, Yoshikawa K, Nishizawa M, Hirayama Y, Kobayashi E, Seyama K, Hino O (January 2000). "Analysis of all exons of TSC1 and TSC2 genes for germline mutations in Japanese patients with tuberous sclerosis: report of 10 mutations". American Journal of Medical Genetics. 90 (2): 123–6. doi:10.1002/(SICI)1096-8628(20000117)90:2<123::AID-AJMG7>3.0.CO;2-L. PMID 10607950.
Lamb RF, Roy C, Diefenbach TJ, Vinters HV, Johnson MW, Jay DG, Hall A (May 2000). "The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho". Nature Cell Biology. 2 (5): 281–7. doi:10.1038/35010550. PMID 10806479. S2CID 25353057.
Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G, Hengstschläger M (July 2000). "The TSC1 gene product, hamartin, negatively regulates cell proliferation". Human Molecular Genetics. 9 (12): 1721–7. doi:10.1093/hmg/9.12.1721. PMID 10915759.
Murthy V, Stemmer-Rachamimov AO, Haddad LA, Roy JE, Cutone AN, Beauchamp RL, Smith N, Louis DN, Ramesh V (March 2001). "Developmental expression of the tuberous sclerosis proteins tuberin and hamartin". Acta Neuropathologica. 101 (3): 202–10. doi:10.1007/s004010000269. PMID 11307618. S2CID 8067136.
Catania MG, Mischel PS, Vinters HV (July 2001). "Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B". Journal of Neuropathology and Experimental Neurology. 60 (7): 711–23. doi:10.1093/jnen/60.7.711. PMID 11444800.

پیوند به بیرون

خلاصه‌ای از اطلاعات ساختاری موجود در بانک داده پروتئین برای یونی‌پروت: Q92574 (Hamartin) در PDBe-KB.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000026812 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: TSC1 tuberous sclerosis 1".

[pmid23435171-5] Papadakis M, Hadley G, Xilouri M, Hoyte LC, Nagel S, McMenamin MM, Tsaknakis G, Watt SM, Drakesmith CW, Chen R, Wood MJ, Zhao Z, Kessler B, Vekrellis K, Buchan AM (March 2013). "Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy". Nature Medicine. 19 (3): 351–7. doi:10.1038/nm.3097. PMC 3744134. PMID 23435171.

[:0-6] Woodford MR, Sager RA, Marris E, Dunn DM, Blanden AR, Murphy RL, Rensing N, Shapiro O, Panaretou B, Prodromou C, Loh SN, Gutmann DH, Bourboulia D, Bratslavsky G, Wong M, Mollapour M (December 2017). "Tumor suppressor Tsc1 is a new Hsp90 co-chaperone that facilitates folding of kinase and non-kinase clients". The EMBO Journal. 36 (24): 3650–3665. doi:10.15252/embj.201796700. PMC 5730846. PMID 29127155.

[pmid16339216-7] ۷٫۰ ^۷٫۱ Astrinidis A, Senapedis W, Henske EP (January 2006). "Hamartin, the tuberous sclerosis complex 1 gene product, interacts with polo-like kinase 1 in a phosphorylation-dependent manner". Human Molecular Genetics. 15 (2): 287–97. doi:10.1093/hmg/ddi444. PMID 16339216.

[pmid12167664-8] Dan HC, Sun M, Yang L, Feldman RI, Sui XM, Ou CC, Nellist M, Yeung RS, Halley DJ, Nicosia SV, Pledger WJ, Cheng JQ (September 2002). "Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin". The Journal of Biological Chemistry. 277 (38): 35364–70. doi:10.1074/jbc.M205838200. PMID 12167664.

[pmid11741833-9] Hodges AK, Li S, Maynard J, Parry L, Braverman R, Cheadle JP, DeClue JE, Sampson JR (December 2001). "Pathological mutations in TSC1 and TSC2 disrupt the interaction between hamartin and tuberin". Human Molecular Genetics. 10 (25): 2899–905. doi:10.1093/hmg/10.25.2899. PMID 11741833.

[pmid11290735-10] Aicher LD, Campbell JS, Yeung RS (June 2001). "Tuberin phosphorylation regulates its interaction with hamartin. Two proteins involved in tuberous sclerosis". The Journal of Biological Chemistry. 276 (24): 21017–21. doi:10.1074/jbc.C100136200. PMID 11290735.

[pmid9580671-11] van Slegtenhorst M, Nellist M, Nagelkerken B, Cheadle J, Snell R, van den Ouweland A, Reuser A, Sampson J, Halley D, van der Sluijs P (June 1998). "Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products". Human Molecular Genetics. 7 (6): 1053–7. doi:10.1093/hmg/7.6.1053. PMID 9580671.

[pmid12176984-12] Nellist M, Goedbloed MA, de Winter C, Verhaaf B, Jankie A, Reuser AJ, van den Ouweland AM, van der Sluijs P, Halley DJ (October 2002). "Identification and characterization of the interaction between tuberin and 14-3-3zeta". The Journal of Biological Chemistry. 277 (42): 39417–24. doi:10.1074/jbc.M204802200. PMID 12176984.

[pmid15340059-13] Li Y, Inoki K, Guan KL (September 2004). "Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity". Molecular and Cellular Biology. 24 (18): 7965–75. doi:10.1128/MCB.24.18.7965-7975.2004. PMC 515062. PMID 15340059.

[pmid12511557-14] Mak BC, Takemaru K, Kenerson HL, Moon RT, Yeung RS (February 2003). "The tuberin-hamartin complex negatively regulates beta-catenin signaling activity". The Journal of Biological Chemistry. 278 (8): 5947–51. doi:10.1074/jbc.C200473200. PMID 12511557.

[pmid15851026-15] Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP (April 2005). "Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis". Cell. 121 (2): 179–93. doi:10.1016/j.cell.2005.02.031. PMID 15851026. S2CID 18663447.

[pmid16636147-16] Cai SL, Tee AR, Short JD, Bergeron JM, Kim J, Shen J, Guo R, Johnson CL, Kiguchi K, Walker CL (April 2006). "Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning". The Journal of Cell Biology. 173 (2): 279–89. doi:10.1083/jcb.200507119. PMC 2063818. PMID 16636147.

[pmid17077083-17] Cao Y, Kamioka Y, Yokoi N, Kobayashi T, Hino O, Onodera M, Mochizuki N, Nakae J (December 2006). "Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway". The Journal of Biological Chemistry. 281 (52): 40242–51. doi:10.1074/jbc.M608116200. PMID 17077083.

[pmid14651849-18] Inoki K, Zhu T, Guan KL (November 2003). "TSC2 mediates cellular energy response to control cell growth and survival". Cell. 115 (5): 577–90. doi:10.1016/S0092-8674(03)00929-2. PMID 14651849. S2CID 18173817.

[pmid15963462-19] Nellist M, Burgers PC, van den Ouweland AM, Halley DJ, Luider TM (August 2005). "Phosphorylation and binding partner analysis of the TSC1-TSC2 complex". Biochemical and Biophysical Research Communications. 333 (3): 818–26. doi:10.1016/j.bbrc.2005.05.175. PMID 15963462.

[pmid16424383-20] Goncharova EA, Goncharov DA, Spaits M, Noonan DJ, Talovskaya E, Eszterhas A, Krymskaya VP (May 2006). "Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2". American Journal of Respiratory Cell and Molecular Biology. 34 (5): 561–72. doi:10.1165/rcmb.2005-0300OC. PMC 2644221. PMID 16424383.

[pmid14551205-21] Astrinidis A, Senapedis W, Coleman TR, Henske EP (December 2003). "Cell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin B". The Journal of Biological Chemistry. 278 (51): 51372–9. doi:10.1074/jbc.M303956200. PMID 14551205.

[pmid11741832-22] Nellist M, Verhaaf B, Goedbloed MA, Reuser AJ, van den Ouweland AM, Halley DJ (December 2001). "TSC2 missense mutations inhibit tuberin phosphorylation and prevent formation of the tuberin-hamartin complex". Human Molecular Genetics. 10 (25): 2889–98. doi:10.1093/hmg/10.25.2889. PMID 11741832.

[pmid11175345-23] Benvenuto G, Li S, Brown SJ, Braverman R, Vass WC, Cheadle JP, Halley DJ, Sampson JR, Wienecke R, DeClue JE (December 2000). "The tuberous sclerosis-1 (TSC1) gene product hamartin suppresses cell growth and augments the expression of the TSC2 product tuberin by inhibiting its ubiquitination". Oncogene. 19 (54): 6306–16. doi:10.1038/sj.onc.1204009. PMID 11175345.

[pmid10807585-24] Murthy V, Haddad LA, Smith N, Pinney D, Tyszkowski R, Brown D, Ramesh V (May 2000). "Similarities and differences in the subcellular localization of hamartin and tuberin in the kidney". American Journal of Physiology. Renal Physiology. 278 (5): F737–46. doi:10.1152/ajprenal.2000.278.5.F737. PMID 10807585.

[pmid10915759-25] Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G, Hengstschläger M (July 2000). "The TSC1 gene product, hamartin, negatively regulates cell proliferation". Human Molecular Genetics. 9 (12): 1721–7. doi:10.1093/hmg/9.12.1721. PMID 10915759.

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