Lck

LCK
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: E9PI33 PDBe E9PI33 RCSB
فهرست شناسه‌های PDB
	1BHF, 1BHH, 1CWD, 1CWE, 1FBZ, 1H92, 1IJR, 1KIK, 1LCJ, 1LCK, 1LKK, 1LKL, 1Q68, 1Q69, 1QPC, 1QPD, 1QPE, 1QPJ, 1X27, 2IIM, 2OF2, 2OF4, 2OFU, 2OFV, 2OG8, 2PL0, 2ZM1, 2ZM4, 2ZYB, 3AC1, 3AC2, 3AC3, 3AC4, 3AC5, 3AC8, 3ACJ, 3ACK, 3AD4, 3AD5, 3AD6, 3B2W, 3BRH, 3BYM, 3BYO, 3BYS, 3BYU, 3KMM, 3KXZ, 3LCK, 3MPM, 4D8K, 4C3F
معین‌کننده‌ها
نام‌های دیگر	LCK, LCK proto-oncogene, Src family tyrosine kinase, IMD22, LSK, YT16, p56lck, pp58lck
شناسه‌های بیرونی	OMIM: 153390 MGI: 96756 HomoloGene: 3911 GeneCards: LCK
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	129,467,434 bp
الگوی گسترش RNA
	; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • CD4 receptor binding; • ATPase binding; • SH2 domain binding; • CD8 receptor binding; • phosphatidylinositol 3-kinase binding; • protein C-terminus binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • identical protein binding; • protein phosphatase binding; • ATP binding; • protein kinase binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • kinase activity; • protein serine/threonine phosphatase activity; • non-membrane spanning protein tyrosine kinase activity; • phosphotyrosine residue binding; • protein tyrosine kinase activity; • T cell receptor binding; • signaling receptor binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • membrane; • extrinsic component of cytoplasmic side of plasma membrane; • immunological synapse; • extracellular exosome; • pericentriolar material; • لیپید رفت; • پوسته یاخته;
فرایند زیستی	• B cell receptor signaling pathway; • release of sequestered calcium ion into cytosol; • هماتوپوئز; • فسفرگیری; • transmembrane receptor protein tyrosine kinase signaling pathway; • positive regulation of T cell receptor signaling pathway; • T cell costimulation; • GO:0019049، GO:0030683 mitigation of host defenses by virus; • platelet activation; • T cell differentiation; • regulation of cell population proliferation; • cellular zinc ion homeostasis; • regulation of lymphocyte activation; • peptidyl-tyrosine autophosphorylation; • T cell receptor signaling pathway; • positive regulation of intrinsic apoptotic signaling pathway; • leukocyte migration; • positive regulation of T cell activation; • GO:0016576 protein dephosphorylation; • دستگاه ایمنی ذاتی; • phosphatidylinositol phosphate biosynthetic process; • GO:0022415 viral process; • protein phosphorylation; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • کوچ یاخته; • peptidyl-tyrosine phosphorylation; • interleukin-7-mediated signaling pathway; • positive regulation of protein kinase B signaling; • دگرگونی یاخته‌; • positive regulation of heterotypic cell-cell adhesion; • positive regulation of leukocyte cell-cell adhesion;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	3932
	16818
	ENSG00000182866
	ENSMUSG00000000409
	E9PI33 P06239، E9PI33
	P06240
	NM_005356، XM_011541453، NM_001330468، XM_024447046، XM_024447047، XM_047420399، XM_047420403 NM_001042771، NM_005356، XM_011541453، NM_001330468، XM_024447046، XM_024447047، XM_047420399، XM_047420403
	NM_001162433، NM_010693، XM_006502818، XM_030253275 NM_001162432، NM_001162433، NM_010693، XM_006502818، XM_030253275
	NP_001317397، NP_005347، XP_011539755، XP_024302814، XP_024302815 NP_001036236، NP_001317397، NP_005347، XP_011539755، XP_024302814، XP_024302815
	NP_001155905، NP_034823، XP_006502881، XP_030109135 NP_001155904، NP_001155905، NP_034823، XP_006502881، XP_030109135
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

تیروزین پروتئین کینازِ اختصاصیِ لنفوسیت‌ها (انگلیسی: Lymphocyte-specific protein tyrosine kinase) یک پروتئین به وزن مولکولی ۵۶ کیلو دالتون است که در درون لنفوسیت‌های دستگاه ایمنی یافت می‌شود. این پروتئین یک تیروزین کیناز است که موجب فسفرگیری ریشه‌های تیروزینی برخی پروتئین‌ها می‌گردد که در مسیرهای سیگنالینگ (علامت‌دهی) درون‌ سلولی نقش دارند.

بیشترین میزان پروتئین Lck در لنفوسیت تی، به‌ویژه در لنفوسیت تی کمک‌کننده و لنفوسیت تی کشنده یافت می‌شود.^[۴]^[۵]

این پروتئین در فسفرگیری دومین SH2، پروتئین کیناز سی، CD3، PI-3K و RASA1 نقش دارد.

پروتئین Lck با DLG1^[۶] و PTPRC^[۷]^[۸] تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000000409 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF (July 1988). "The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 85 (14): 5190–4. doi:10.1073/pnas.85.14.5190. PMC 281714. PMID 2455897.
↑ Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (May 1989). "The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex". Proceedings of the National Academy of Sciences of the United States of America. 86 (9): 3277–81. doi:10.1073/pnas.86.9.3277. PMC 287114. PMID 2470098.
↑ Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH (October 1997). "Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes". The Journal of Biological Chemistry. 272 (43): 26899–904. doi:10.1074/jbc.272.43.26899. PMID 9341123.
↑ Koretzky GA, Kohmetscher M, Ross S (April 1993). "CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line". The Journal of Biological Chemistry. 268 (12): 8958–64. PMID 8473339.
↑ Ng DH, Watts JD, Aebersold R, Johnson P (January 1996). "Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro". The Journal of Biological Chemistry. 271 (3): 1295–300. doi:10.1074/jbc.271.3.1295. PMID 8576115.

مشارکت‌کنندگان ویکی‌پدیا. «Lck». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

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پیوند به بیرون

lck Kinase در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000000409 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Rudd CE, Trevillyan JM, Dasgupta JD, Wong LL, Schlossman SF (July 1988). "The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes". Proceedings of the National Academy of Sciences of the United States of America. 85 (14): 5190–4. doi:10.1073/pnas.85.14.5190. PMC 281714. PMID 2455897.

[5] Barber EK, Dasgupta JD, Schlossman SF, Trevillyan JM, Rudd CE (May 1989). "The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex". Proceedings of the National Academy of Sciences of the United States of America. 86 (9): 3277–81. doi:10.1073/pnas.86.9.3277. PMC 287114. PMID 2470098.

[pmid9341123-6] Hanada T, Lin L, Chandy KG, Oh SS, Chishti AH (October 1997). "Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes". The Journal of Biological Chemistry. 272 (43): 26899–904. doi:10.1074/jbc.272.43.26899. PMID 9341123.

[pmid8473339-7] Koretzky GA, Kohmetscher M, Ross S (April 1993). "CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line". The Journal of Biological Chemistry. 268 (12): 8958–64. PMID 8473339.

[pmid8576115-8] Ng DH, Watts JD, Aebersold R, Johnson P (January 1996). "Demonstration of a direct interaction between p56lck and the cytoplasmic domain of CD45 in vitro". The Journal of Biological Chemistry. 271 (3): 1295–300. doi:10.1074/jbc.271.3.1295. PMID 8576115.

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