ویکی‌پدیا

GRB2

پروتئین شمارهٔ ۲ متصل به گیرندهٔ فاکتور رشد (انگلیسی: Growth factor receptor-bound protein 2) که به‌اختصار «Grb2» نامیده می‌شود، یک پروتئین وفق‌دهنده ترارسانی پیام است که در فرایند ترارسانی پیام/ارتباطات سلولی دخالت دارد. در انسان، این پروتئین توسط ژن «GRB2» کدگذاری می‌شود.[۴][۵] پروتئینی که توسط ژن «GRB2» ساخته می‌شود به گیرنده‌هایی چون گیرنده فاکتور رشد اپیدرمی اتصال می‌یابد.

GRB2
ساختارهای موجود
PDBجستجوی هم‌ساخت‌شناسی: PDBe RCSB
معین‌کننده‌ها
نام‌های دیگرGRB2, ASH, EGFRBP-Grb3-3, MST084, MSTP084, NCKAP2, growth factor receptor bound protein 2
شناسه‌های بیرونیOMIM: 108355 MGI: 95805 HomoloGene: 1576 GeneCards: GRB2
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

2885

14784

آنسامبل

ENSG00000177885

ENSMUSG00000059923

یونی‌پروت

P62993

Q60631

RefSeq (mRNA)

NM_002086 NM_203506، NM_002086

NM_001313936، NM_001313937 NM_008163، NM_001313936، NM_001313937

RefSeq (پروتئین)

NP_987102 NP_002077، NP_987102

NP_001300866، NP_032189 NP_001300865، NP_001300866، NP_032189

موقعیت (UCSC)ن/مChr : 115.53 – 115.6 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

تخریب این ژن در موش‌های آزمایشگاهی باعث شد تا رویان آنها در مراحل اولیهٔ تشکیل از بین بروند.

فعل و انفعالات

ویرایش

مشخص شده است که Grb2 با پروتئین های زیر تعامل پروتئین-پروتئین دارد:

منابع

ویرایش
  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000059923 - Ensembl, May 2017
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  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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بیشتر بخوانید

ویرایش
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