SH3KBP1

SH3KBP1
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	2BZ8, 2K6D, 2K9G, 2O2O, 2YDL, 5ABS, 2N64
معین‌کننده‌ها
نام‌های دیگر	SH3KBP1, CD2BP3, CIN85, GIG10, HSB-1, HSB1, MIG18, SH3 domain containing kinase binding protein 1, IMD61, AGMX2
شناسه‌های بیرونی	OMIM: 300374 MGI: 1889583 HomoloGene: 10971 GeneCards: SH3KBP1
موقعیت ژن (انسان)
کروموزوم	کروموزوم X (انسان)
پایان	19,887,600 bp
موقعیت ژن (موش)
کروموزوم	کروموزوم X (موش)
پایان	158,761,065 bp
هستی‌شناسی ژن
عملکرد ملکولی	• SH3 domain binding; • GO:0001948، GO:0016582 پیوند پروتئینی;
ترکیبات سلولی	• سیتوزول; • membrane; • cell-cell junction; • focal adhesion; • پوسته یاخته; • endocytic vesicle; • سیناپس; • پیوند میان‌یاخته‌ای; • neuron projection; • اسکلت سلولی; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle; • سیتوپلاسم;
فرایند زیستی	• negative regulation of epidermal growth factor receptor signaling pathway; • اندوسیتوز; • cell-cell signaling; • cytoskeleton organization; • regulation of cell shape; • کوچ یاخته; • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته; • membrane organization; • هدایت آسه; • actin filament organization;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	30011
	58194
	ENSG00000147010
	ENSMUSG00000040990
	Q96B97; Q5JPT2
	Q8R550
	NM_001024666، NM_001184960، NM_031892، XM_011545498، XM_011545499، XM_011545500، XM_011545502، XM_017029460، XM_017029461، XM_017029467، XM_017029468، XM_017029469، NM_001353890، NM_001353891، NM_001353892، NM_001353893، NM_001353894، NM_001353895، NM_001353897، XM_047442039، XM_047442040، XM_047442041، XM_047442042، XM_047442043، XM_047442044، XM_047442045، XM_047442046، XM_047442047، XM_047442048، XM_047442049، XM_047442050 XM_011545503، NM_001024666، NM_001184960، NM_031892، XM_011545498، XM_011545499، XM_011545500، XM_011545502، XM_017029460، XM_017029461، XM_017029467، XM_017029468، XM_017029469، NM_001353890، NM_001353891، NM_001353892، NM_001353893، NM_001353894، NM_001353895، NM_001353897، XM_047442039، XM_047442040، XM_047442041، XM_047442042، XM_047442043، XM_047442044، XM_047442045، XM_047442046، XM_047442047، XM_047442048، XM_047442049، XM_047442050
	NM_001135728، NM_001290661، NM_001290664، NM_021389، NR_110969، NR_110970، XM_006528924، XM_006528925، XM_006528927، XM_006528928، XM_006528929، XM_006528932، XM_011247851، XM_017318584، XM_017318586، XM_030251430، XM_030251431، XM_030251432، XM_030251433، NM_001374701، XM_036162053، XM_036162054 NM_001135727، NM_001135728، NM_001290661، NM_001290664، NM_021389، NR_110969، NR_110970، XM_006528924، XM_006528925، XM_006528927، XM_006528928، XM_006528929، XM_006528932، XM_011247851، XM_017318584، XM_017318586، XM_030251430، XM_030251431، XM_030251432، XM_030251433، NM_001374701، XM_036162053، XM_036162054
	NP_001171889، NP_114098، XP_011543800، XP_011543801، XP_011543802، XP_011543804، XP_011543805، XP_016884949، XP_016884950، XP_016884953، XP_016884954، XP_016884956، XP_016884957، XP_016884958، NP_001340819، NP_001340820، NP_001340821، NP_001340822، NP_001340823، NP_001340824، NP_001340826 NP_001019837، NP_001171889، NP_114098، XP_011543800، XP_011543801، XP_011543802، XP_011543804، XP_011543805، XP_016884949، XP_016884950، XP_016884953، XP_016884954، XP_016884956، XP_016884957، XP_016884958، NP_001340819، NP_001340820، NP_001340821، NP_001340822، NP_001340823، NP_001340824، NP_001340826
	NP_001129200، NP_001277590، NP_001277593، NP_067364، XP_006528987، XP_006528988، XP_006528990، XP_006528991، XP_006528992، XP_006528995، XP_011246153، XP_017174073، XP_017174075، XP_030107290، XP_030107291، XP_030107292، XP_030107293، NP_001361630، XP_036017946، XP_036017947 NP_001129199، NP_001129200، NP_001277590، NP_001277593، NP_067364، XP_006528987، XP_006528988، XP_006528990، XP_006528991، XP_006528992، XP_006528995، XP_011246153، XP_017174073، XP_017174075، XP_030107290، XP_030107291، XP_030107292، XP_030107293، NP_001361630، XP_036017946، XP_036017947
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین شمارهٔ ۱ متصل‌شونده به کیناز و حاوی دومین SH3 (انگلیسی: SH3 domain-containing kinase-binding protein 1) یک پروتئین وفق‌دهنده ترارسانی پیام است که در انسان توسط ژن «SH3KBP1» کُدگذاری می‌شود.^[۵]^[۶]

این پروتئین با SH3GL3^[۷] و گیرنده فاکتور رشد اپیدرمی^[۸]^[۹] تعامل پروتئین-پروتئین دارد.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000147010 - Ensembl, May 2017
↑ ^۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000040990 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
↑ Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
↑ Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
↑ Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.
↑ Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.

مشارکت‌کنندگان ویکی‌پدیا. «SH3KBP1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۹ ژوئن ۲۰۱۹.

برای مطالعهٔ بیشتر

Salvatore P, Hanash CR, Kido Y, Imai Y, Accili D (March 1998). "Identification of sirm, a novel insulin-regulated SH3 binding protein that associates with Grb-2 and FYN". The Journal of Biological Chemistry. 273 (12): 6989–97. doi:10.1074/jbc.273.12.6989. PMID 9507006.
Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (December 1998). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". The EMBO Journal. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.
Take H, Watanabe S, Takeda K, Yu ZX, Iwata N, Kajigaya S (February 2000). "Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl". Biochemical and Biophysical Research Communications. 268 (2): 321–8. doi:10.1006/bbrc.2000.2147. PMID 10679202.
Chen B, Borinstein SC, Gillis J, Sykes VW, Bogler O (June 2000). "The glioma-associated protein SETA interacts with AIP1/Alix and ALG-2 and modulates apoptosis in astrocytes". The Journal of Biological Chemistry. 275 (25): 19275–81. doi:10.1074/jbc.M908994199. PMID 10858458.
Gout I, Middleton G, Adu J, Ninkina NN, Drobot LB, Filonenko V, Matsuka G, Davies AM, Waterfield M, Buchman VL (August 2000). "Negative regulation of PI 3-kinase by Ruk, a novel adaptor protein". The EMBO Journal. 19 (15): 4015–25. doi:10.1093/emboj/19.15.4015. PMC 306608. PMID 10921882.
Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S (November 2000). "Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes". Biochemical and Biophysical Research Communications. 278 (1): 167–74. doi:10.1006/bbrc.2000.3760. PMID 11071869.
Borinstein SC, Hyatt MA, Sykes VW, Straub RE, Lipkowitz S, Boulter J, Bogler O (December 2000). "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular Signalling. 12 (11–12): 769–79. doi:10.1016/S0898-6568(00)00129-7. PMID 11152963.
Narita T, Amano F, Yoshizaki K, Nishimoto N, Nishimura T, Tajima T, Namiki H, Taniyama T (2001). "Assignment of SH3KBP1 to human chromosome band Xp22.1-->p21.3 by in situ hybridization". Cytogenetics and Cell Genetics. 93 (1–2): 133–4. doi:10.1159/000056966. PMID 11474197.
Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.
Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
Scott MP, Zappacosta F, Kim EY, Annan RS, Miller WT (August 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". The Journal of Biological Chemistry. 277 (31): 28238–46. doi:10.1074/jbc.M202783200. PMID 12029088.
Verdier F, Valovka T, Zhyvoloup A, Drobot LB, Buchman V, Waterfield M, Gout I (July 2002). "Ruk is ubiquitinated but not degraded by the proteasome". European Journal of Biochemistry. 269 (14): 3402–8. doi:10.1046/j.1432-1033.2002.03031.x. PMID 12135478.
Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
Haglund K, Shimokawa N, Szymkiewicz I, Dikic I (September 2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors". Proceedings of the National Academy of Sciences of the United States of America. 99 (19): 12191–6. doi:10.1073/pnas.192462299. PMC 129420. PMID 12218189.
Buchman VL, Luke C, Borthwick EB, Gout I, Ninkina N (July 2002). "Organization of the mouse Ruk locus and expression of isoforms in mouse tissues". Gene. 295 (1): 13–17. doi:10.1016/S0378-1119(02)00821-1. PMID 12242006.
Tibaldi EV, Reinherz EL (March 2003). "CD2BP3, CIN85 and the structurally related adaptor protein CMS bind to the same CD2 cytoplasmic segment, but elicit divergent functional activities". International Immunology. 15 (3): 313–29. doi:10.1093/intimm/dxg032. PMID 12618476.
Hutchings NJ, Clarkson N, Chalkley R, Barclay AN, Brown MH (June 2003). "Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85". The Journal of Biological Chemistry. 278 (25): 22396–403. doi:10.1074/jbc.M302540200. PMID 12690097.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCh38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCh38: Ensembl release 89: ENSG00000147010 - Ensembl, May 2017

[refGRCm38Ensembl-2] ۲٫۰ ^۲٫۱ ^۲٫۲ GRCm38: Ensembl release 89: ENSMUSG00000040990 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8889549-5] Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, et al. (September 1996). "Generation and analysis of 280,000 human expressed sequence tags". Genome Research. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.

[pmid7566098-6] Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.

[pmid11894096-7] Petrelli A, Gilestro GF, Lanzardo S, Comoglio PM, Migone N, Giordano S (March 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.

[pmid11894095-8] Soubeyran P, Kowanetz K, Szymkiewicz I, Langdon WY, Dikic I (March 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature. 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.

[pmid12177062-9] Szymkiewicz I, Kowanetz K, Soubeyran P, Dinarina A, Lipkowitz S, Dikic I (October 2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases". The Journal of Biological Chemistry. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.

[۵]

[۶]

[۱]

[۲]

[۳]

[۴]

[۷]

[۸]

[۹]