FGR

FGR
معین‌کننده‌ها
نام‌های دیگر	FGR, SRC2, c-fgr, c-src2, p55-Fgr, p55c-fgr, p58-Fgr, p58c-fgr, FGR proto-oncogene, Src family tyrosine kinase
شناسه‌های بیرونی	OMIM: 164940 MGI: 95527 HomoloGene: 3842 GeneCards: FGR
موقعیت ژن (موش)
کروموزوم	کروموزوم ۴ (موش)
پایان	132,729,221 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• transferase activity; • nucleotide binding; • protein kinase activity; • immunoglobulin receptor binding; • kinase activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • Fc-gamma receptor I complex binding; • ATP binding; • protein kinase binding; • protein tyrosine kinase activity; • non-membrane spanning protein tyrosine kinase activity; • phosphotyrosine residue binding; • signaling receptor binding;
ترکیبات سلولی	• سیتوپلاسم; • سیتوزول; • cell projection; • membrane; • extrinsic component of cytoplasmic side of plasma membrane; • mitochondrial intermembrane space; • ruffle membrane; • میتوکندری; • actin cytoskeleton; • mitochondrial inner membrane; • extracellular exosome; • اسکلت سلولی; • extracellular region; • پوسته یاخته; • aggresome; • secretory granule lumen;
فرایند زیستی	• دگرگونی یاخته‌; • regulation of innate immune response; • Fc-gamma receptor signaling pathway involved in phagocytosis; • فسفرگیری; • transmembrane receptor protein tyrosine kinase signaling pathway; • immune system process; • positive regulation of cell migration; • response to virus; • positive regulation of mast cell degranulation; • immune response-regulating cell surface receptor signaling pathway; • positive regulation of phosphatidylinositol 3-kinase activity; • protein phosphorylation; • regulation of cell population proliferation; • regulation of cell shape; • peptidyl-tyrosine autophosphorylation; • integrin-mediated signaling pathway; • protein autophosphorylation; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • regulation of protein kinase activity; • regulation of phagocytosis; • GO:0051637 defense response to Gram-positive bacterium; • کوچ یاخته; • دستگاه ایمنی ذاتی; • neutrophil degranulation; • bone mineralization; • skeletal system morphogenesis;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2268
	14191
	ENSG00000000938
	ENSMUSG00000028874
	P09769
	P14234
	NM_001042747، NM_005248 NM_001042729، NM_001042747، NM_005248
	XM_006538544، XM_006538545 NM_010208، XM_006538544، XM_006538545
	NP_001036212، NP_005239، XP_006710515، XP_011539312، XP_011539313، XP_011539314، XP_011539315، XP_011539316، XP_016856162، XP_016856163 NP_001036194، NP_001036212، NP_005239، XP_006710515، XP_011539312، XP_011539313، XP_011539314، XP_011539315، XP_011539316، XP_016856162، XP_016856163
	XP_006538607، XP_006538608 NP_034338، XP_006538607، XP_006538608
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

هومولوگ سرطان‌زای سارکومای ویروسی گربه‌سانان گاردنر-راشد (انگلیسی: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) یک پروتئین است که در انسان توسط ژن «FGR» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین یکی از اعضای خانواده کینازهای Src است و در غشاء سلولی جای دارد و کوچ یاخته و چسبندگی سلولی ناشی از اینتگرین‌ها را کاهش می‌دهد.

عفونت با ویروس اپشتین–بار موجب افزایش بیان ژنی این پروتئین می‌گردد.

این ژن در گربه‌سانان و توسط تیم تحقیقاتی ثریا راشد و موری گاردنر کشف شد.^[۶]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028874 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "of Sciences of the United States of America". 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972. {{cite journal}}: Cite journal requires |journal= (help)
↑ "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".
↑ Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.

مشارکت‌کنندگان ویکی‌پدیا. «FGR (gene)». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ اوت ۲۰۱۹.

برای مطالعهٔ بیشتر

Patel M, Faulkner L, Katz DR, Brickell PM (1991). "The c-fgr proto-oncogene: expression in Epstein-Barr-virus-infected B lymphocytes and in cells of the myelomonocytic and granulocytic lineages". Pathobiology. 59 (4): 289–92. doi:10.1159/000163665. PMID 1652975.
Resh MD (Feb 1994). "Myristylation and palmitylation of Src family members: the fats of the matter". Cell. 76 (3): 411–3. doi:10.1016/0092-8674(94)90104-X. PMID 8313462.
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Tatosyan AG, Mizenina OA (Jan 2000). "Kinases of the Src family: structure and functions". Biochemistry. Biokhimiia. 65 (1): 49–58. PMID 10702640.
Patel MS, Mankoo BS, Brickell PM (Apr 1992). "A polymorphic microsatellite repeat is located close to the promoter region of the c-fgr proto-oncogene (FGR) at chromosome 1p36.2-p36.1". Human Molecular Genetics. 1 (1): 65. doi:10.1093/hmg/1.1.65-a. PMID 1339476.
Link DC, Gutkind SJ, Robbins KC, Ley TJ (May 1992). "Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter". Oncogene. 7 (5): 877–84. PMID 1373875.
Patel M, Leevers SJ, Brickell PM (Feb 1990). "Structure of the complete human c-fgr proto-oncogene and identification of multiple transcriptional start sites". Oncogene. 5 (2): 201–6. PMID 1690869.
Biondi A, Paganin C, Rossi V, Benvestito S, Perlmutter RM, Mantovani A, Allavena P (Mar 1991). "Expression of lineage-restricted protein tyrosine kinase genes in human natural killer cells". European Journal of Immunology. 21 (3): 843–6. doi:10.1002/eji.1830210348. PMID 1826268.
Gutkind JS, Link DC, Katamine S, Lacal P, Miki T, Ley TJ, Robbins KC (Mar 1991). "A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes". Molecular and Cellular Biology. 11 (3): 1500–7. doi:10.1128/MCB.11.3.1500. PMC 369433. PMID 1847500.
Patel M, Leevers SJ, Brickell PM (Feb 1990). "Regulation of c-fgr proto-oncogene expression in Epstein-Barr virus infected B-cell lines". International Journal of Cancer. 45 (2): 342–6. doi:10.1002/ijc.2910450222. PMID 2154410.
Parker RC, Mardon G, Lebo RV, Varmus HE, Bishop JM (Apr 1985). "Isolation of duplicated human c-src genes located on chromosomes 1 and 20". Molecular and Cellular Biology. 5 (4): 831–8. doi:10.1128/MCB.5.4.831. PMC 366788. PMID 2581127.
Brickell PM, Patel M (Dec 1988). "Structure and expression of c-fgr protooncogene mRNA in Epstein-Barr virus converted cell lines". British Journal of Cancer. 58 (6): 704–9. doi:10.1038/bjc.1988.294. PMC 2246855. PMID 2852026.
Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family". Proceedings of the National Academy of Sciences of the United States of America. 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972.
Cheah MS, Ley TJ, Tronick SR, Robbins KC (1986). "fgr proto-oncogene mRNA induced in B lymphocytes by Epstein-Barr virus infection". Nature. 319 (6050): 238–40. doi:10.1038/319238a0. PMID 3003578.
Nishizawa M, Semba K, Yoshida MC, Yamamoto T, Sasaki M, Toyoshima K (Feb 1986). "Structure, expression, and chromosomal location of the human c-fgr gene". Molecular and Cellular Biology. 6 (2): 511–7. doi:10.1128/MCB.6.2.511. PMC 367540. PMID 3023853.
Katamine S, Notario V, Rao CD, Miki T, Cheah MS, Tronick SR, Robbins KC (Jan 1988). "Primary structure of the human fgr proto-oncogene product p55c-fgr". Molecular and Cellular Biology. 8 (1): 259–66. doi:10.1128/MCB.8.1.259. PMC 363113. PMID 3275868.
Inoue K, Ikawa S, Semba K, Sukegawa J, Yamamoto T, Toyoshima K (1988). "Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9". Oncogene. 1 (3): 301–4. PMID 3330776.
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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000028874 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2995972-4] Tronick SR, Popescu NC, Cheah MS, Swan DC, Amsbaugh SC, Lengel CR, DiPaolo JA, Robbins KC (Oct 1985). "of Sciences of the United States of America". 82 (19): 6595–9. doi:10.1073/pnas.82.19.6595. PMC 391256. PMID 2995972. {{cite journal}}: Cite journal requires |journal= (help)

[entrez-5] "Entrez Gene: FGR Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog".

[pmid6175084-6] Rasheed S, Barbacid M, Aaronson S, Gardner MB (Feb 1982). "Origin and biological properties of a new feline sarcoma virus". Virology. 117 (1): 238–44. doi:10.1016/0042-6822(82)90522-0. PMID 6175084.

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