گیرنده بتای رتینوئیک اسید

RARB
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1HRA, 1XAP, 4DM6, 4DM8, 4JYG, 4JYH, 4JYI
معین‌کننده‌ها
نام‌های دیگر	RARB, HAP, MCOPS12, NR1B2, RRB2, RARbeta1, retinoic acid receptor beta, RARbeta
شناسه‌های بیرونی	OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	6,038,924 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• DNA binding; • sequence-specific DNA binding; • RNA polymerase II transcription regulatory region sequence-specific DNA binding; • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • metal ion binding; • steroid hormone receptor activity; • GO:0001948، GO:0016582 پیوند پروتئینی; • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • GO:0032403 protein-containing complex binding; • retinoid X receptor binding; • GO:0000975 transcription cis-regulatory region binding; • transcription factor binding; • nuclear receptor coactivator activity; • signaling receptor activity; • GO:0038050، GO:0004886، GO:0038051 nuclear receptor activity;
ترکیبات سلولی	• سیتوپلاسم; • نوکلئوپلاسم; • هسته یاخته; • RNA polymerase II transcription regulator complex;
فرایند زیستی	• growth plate cartilage development; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • عصب‌زایی; • ureteric bud development; • GO:0009373 regulation of transcription, DNA-templated; • negative regulation of cartilage development; • multicellular organism growth; • embryonic eye morphogenesis; • positive regulation of programmed cell death; • negative regulation of apoptotic process; • GO:1901227 negative regulation of transcription by RNA polymerase II; • retinal pigment epithelium development; • transcription, DNA-templated; • outflow tract septum morphogenesis; • negative regulation of chondrocyte differentiation; • retinoic acid receptor signaling pathway; • regulation of myelination; • retina development in camera-type eye; • positive regulation of neuron differentiation; • positive regulation of cell population proliferation; • positive regulation of apoptotic process; • ventricular cardiac muscle cell differentiation; • transcription initiation from RNA polymerase II promoter; • bone development; • embryonic digestive tract development; • striatum development; • GO:0072468 ورارسانی پیام; • negative regulation of cell population proliferation; • glandular epithelial cell development; • steroid hormone mediated signaling pathway; • embryonic hindlimb morphogenesis; • liver development; • multicellular organism development; • hormone-mediated signaling pathway; • دگرگونی یاخته‌; • response to retinoic acid; • response to lipid; • gland development; • bone morphogenesis; • epithelium development; • cellular response to retinoic acid;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	5915
	218772
	ENSG00000077092
	ENSMUSG00000017491
	P10826; Q5QHG3
	P22605
	NM_000965، NM_001290216، NM_001290217، NM_001290266، NM_001290276، NM_001290277، NM_001290300، NM_016152، NR_110892 NR_110893، NM_000965، NM_001290216، NM_001290217، NM_001290266، NM_001290276، NM_001290277، NM_001290300، NM_016152، NR_110892
	NM_001289761، NM_001289762، NM_011243 NM_001289760، NM_001289761، NM_001289762، NM_011243
	NP_001277145، NP_001277146، NP_001277195، NP_001277205، NP_001277206، NP_001277229، NP_057236 NP_000956، NP_001277145، NP_001277146، NP_001277195، NP_001277205، NP_001277206، NP_001277229، NP_057236; NP_001277205.1، NP_057236.1 NP_001277146.1، NP_001277205.1، NP_057236.1
	NP_001276690، NP_001276691، NP_035373 NP_001276689، NP_001276690، NP_001276691، NP_035373
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

گیرنده بتای رتینوئیک اسید (انگلیسی: Retinoic acid receptor beta) یا به اختصار RAR-beta، یک پروتئین است که در انسان توسط ژن «RARB» کُدگذاری می‌شود.^[۴]^[۵]

این پروتئین، یک گیرنده هسته‌ای، و یکی از انواع گیرنده‌های رتینوئیک اسید است و نخستین بار، در سرطان کبد (از نوعِ هپاتوسلولار) کشف شد.

اختلال در این ژن همچنین، در ضایعات پیش‌سرطانی سرطان دهانه رحم^[۶] و نیز در سرطان مهبل ناشی از لیکن اسکلروز مهبل^[۷] مشاهده شده‌است.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000017491 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: RARB retinoic acid receptor, beta".
↑ Mattei MG, de Thé H, Mattei JF, Marchio A, Tiollais P, Dejean A (Oct 1988). "Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3". Human Genetics. 80 (2): 189–90. doi:10.1007/BF00702867. PMID 2844650.
↑ Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.
↑ Rotondo JC, Borghi A, Selvatici R, Mazzoni E, Bononi I, Corazza M, Kussini J, Montinari E, Gafà R, Tognon M, Martini F (2018). "Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma". JAMA Dermatology. 154 (7): 819–823. doi:10.1001/jamadermatol.2018.1373. PMC 6128494. PMID 29898214.

مشارکت‌کنندگان ویکی‌پدیا. «Retinoic acid receptor beta». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر

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Berrodin TJ, Marks MS, Ozato K, Linney E, Lazar MA (Sep 1992). "Heterodimerization among thyroid hormone receptor, retinoic acid receptor, retinoid X receptor, chicken ovalbumin upstream promoter transcription factor, and an endogenous liver protein". Molecular Endocrinology. 6 (9): 1468–78. doi:10.1210/me.6.9.1468. PMID 1331778.
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de Thé H, Vivanco-Ruiz MM, Tiollais P, Stunnenberg H, Dejean A (Jan 1990). "Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene". Nature. 343 (6254): 177–80. doi:10.1038/343177a0. PMID 2153268.
Hoffmann B, Lehmann JM, Zhang XK, Hermann T, Husmann M, Graupner G, Pfahl M (Nov 1990). "A retinoic acid receptor-specific element controls the retinoic acid receptor-beta promoter". Molecular Endocrinology. 4 (11): 1727–36. doi:10.1210/mend-4-11-1727. PMID 2177841.
de Thé H, Marchio A, Tiollais P, Dejean A (1988). "A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma". Nature. 330 (6149): 667–70. doi:10.1038/330667a0. PMID 2825037.
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این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000017491 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-4] "Entrez Gene: RARB retinoic acid receptor, beta".

[pmid2844650-5] Mattei MG, de Thé H, Mattei JF, Marchio A, Tiollais P, Dejean A (Oct 1988). "Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3". Human Genetics. 80 (2): 189–90. doi:10.1007/BF00702867. PMID 2844650.

[Rotondo_2015-6] Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.

[Rotondo_2018-7] Rotondo JC, Borghi A, Selvatici R, Mazzoni E, Bononi I, Corazza M, Kussini J, Montinari E, Gafà R, Tognon M, Martini F (2018). "Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma". JAMA Dermatology. 154 (7): 819–823. doi:10.1001/jamadermatol.2018.1373. PMC 6128494. PMID 29898214.

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