پروتئین ۴ ریخت‌زایی استخوان

BMP4
معین‌کننده‌ها
نام‌های دیگر	BMP4, BMP2B, BMP2B1, MCOPS6, OFC11, ZYME, bone morphogenetic protein 4
شناسه‌های بیرونی	OMIM: 112262 MGI: 88180 HomoloGene: 7247 GeneCards: BMP4
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	46,628,126 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• heparin binding; • cytokine activity; • co-receptor binding; • transforming growth factor beta receptor binding; • growth factor activity; • BMP receptor binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • chemoattractant activity;
ترکیبات سلولی	• extracellular region; • extracellular space; • endoplasmic reticulum lumen;
فرایند زیستی	• embryonic skeletal system morphogenesis; • negative regulation of T cell differentiation in thymus; • germ cell development; • skeletal system development; • mesenchymal cell differentiation involved in renal system development; • cardiac septum development; • ureteric bud development; • positive regulation of protein phosphorylation; • renal system process; • positive regulation of endothelial cell differentiation; • negative regulation of immature T cell proliferation in thymus; • bud elongation involved in lung branching; • tendon cell differentiation; • anatomical structure formation involved in morphogenesis; • ureter epithelial cell differentiation; • negative regulation of cell cycle; • mesenchymal to epithelial transition involved in metanephros morphogenesis; • trachea development; • post-embryonic development; • monocyte differentiation; • specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway; • blood vessel endothelial cell proliferation involved in sprouting angiogenesis; • BMP signaling pathway involved in renal system segmentation; • cranial suture morphogenesis; • mesonephros development; • odontogenesis of dentin-containing tooth; • telencephalon regionalization; • negative regulation of chondrocyte differentiation; • blood vessel development; • negative regulation of mitotic nuclear division; • رگ‌زایی; • prostate gland morphogenesis; • positive regulation of ERK1 and ERK2 cascade; • smooth muscle tissue development; • BMP signaling pathway involved in heart induction; • negative regulation of epithelial cell proliferation; • بافت زایی; • metanephric collecting duct development; • inner ear receptor cell differentiation; • mesodermal cell fate determination; • metanephros development; • type B pancreatic cell development; • regulation of pathway-restricted SMAD protein phosphorylation; • negative regulation of cell population proliferation; • steroid hormone mediated signaling pathway; • mammary gland formation; • positive regulation of collagen biosynthetic process; • renal system development; • negative regulation of myoblast differentiation; • cell fate commitment; • common-partner SMAD protein phosphorylation; • glomerular visceral epithelial cell development; • SMAD protein signal transduction; • استخوان‌سازی; • kidney development; • lung development; • ureter smooth muscle cell differentiation; • embryonic digit morphogenesis; • epithelial-mesenchymal cell signaling; • negative regulation of thymocyte apoptotic process; • mesenchymal cell differentiation involved in kidney development; • negative regulation of cell death; • regulation of odontogenesis of dentin-containing tooth; • BMP signaling pathway involved in ureter morphogenesis; • mesenchymal cell proliferation involved in ureteric bud development; • smooth muscle cell differentiation; • lymphoid progenitor cell differentiation; • epithelium development; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • deltoid tuberosity development; • negative regulation of prostatic bud formation; • heart development; • telencephalon development; • branching involved in ureteric bud morphogenesis; • positive regulation of kidney development; • غضروف‌زایی; • embryonic limb morphogenesis; • مپ کیناز; • positive regulation of cartilage development; • lens induction in camera-type eye; • positive regulation of neuron differentiation; • branching involved in prostate gland morphogenesis; • regulation of protein import into nucleus; • positive regulation of cell differentiation; • erythrocyte differentiation; • مسیر سیگنال‌دهی خارپشتی; • camera-type eye development; • secondary heart field specification; • negative regulation of phosphorylation; • regulation of smooth muscle cell differentiation; • regulation of cell fate commitment; • regulation of branching involved in prostate gland morphogenesis; • دگرگونی یاخته‌; • positive regulation of branching involved in lung morphogenesis; • chondrocyte differentiation; • regulation of cartilage development; • organ induction; • positive regulation of epithelial cell proliferation; • epithelial cell proliferation involved in lung morphogenesis; • negative regulation of cell proliferation involved in heart morphogenesis; • negative regulation of apoptotic process; • positive regulation of ossification; • استخوان‌سازی درون‌غضروفی; • regulation of smooth muscle cell proliferation; • regulation of morphogenesis of a branching structure; • BMP signaling pathway; • macrophage differentiation; • negative regulation of metanephric comma-shaped body morphogenesis; • embryonic skeletal system development; • mesenchymal cell proliferation involved in ureter development; • osteoblast differentiation; • hematopoietic progenitor cell differentiation; • positive regulation of BMP signaling pathway; • ساماندهی بیان ژن; • embryonic cranial skeleton morphogenesis; • dorsal/ventral neural tube patterning; • lung alveolus development; • positive regulation of protein binding; • anterior/posterior axis specification; • GO:0045996 negative regulation of transcription, DNA-templated; • positive regulation of epidermal cell differentiation; • branching morphogenesis of an epithelial tube; • trachea formation; • specification of animal organ position; • negative regulation of glomerular mesangial cell proliferation; • positive regulation of smooth muscle cell proliferation; • intermediate mesodermal cell differentiation; • pulmonary artery endothelial tube morphogenesis; • pituitary gland development; • positive regulation of cell death; • lung morphogenesis; • positive regulation of endothelial cell proliferation; • bud dilation involved in lung branching; • positive regulation of cardiac muscle fiber development; • negative regulation of striated muscle tissue development; • positive regulation of cell migration; • negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway; • BMP signaling pathway involved in nephric duct formation; • positive regulation of pathway-restricted SMAD protein phosphorylation; • negative regulation of mesenchymal cell proliferation involved in ureter development; • mesoderm formation; • cellular response to growth factor stimulus; • glomerular capillary formation; • bronchus development; • positive regulation of endothelial cell migration; • multicellular organism development; • negative regulation of metanephric S-shaped body morphogenesis; • neural tube closure; • vasculature development; • embryonic morphogenesis; • protein localization to nucleus; • positive regulation of apoptotic process; • embryonic skeletal joint morphogenesis; • regulation of cell differentiation; • negative regulation of branching involved in ureteric bud morphogenesis; • mesodermal cell differentiation; • neuron fate commitment; • forebrain development; • cloacal septation; • bone development; • camera-type eye morphogenesis; • positive regulation of SMAD protein signal transduction; • negative regulation of glomerulus development; • embryonic hindlimb morphogenesis; • positive chemotaxis; • outflow tract morphogenesis; • odontogenesis; • GO:1901227 negative regulation of transcription by RNA polymerase II; • epithelial to mesenchymal transition involved in endocardial cushion formation; • cardiac jelly development; • cellular response to BMP stimulus; • positive regulation of osteoblast differentiation; • epithelial tube branching involved in lung morphogenesis; • cardiac muscle cell differentiation; • apoptotic process involved in endocardial cushion morphogenesis; • muscular septum morphogenesis; • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II; • positive regulation of bone mineralization; • cardiac right ventricle morphogenesis; • outflow tract septum morphogenesis; • membranous septum morphogenesis; • aortic valve morphogenesis; • pulmonary valve morphogenesis; • endocardial cushion development; • endoderm development; • coronary vasculature development; • BMP signaling pathway involved in heart development; • pharyngeal arch artery morphogenesis; • positive regulation of cell proliferation involved in outflow tract morphogenesis; • negative regulation of extrinsic apoptotic signaling pathway; • regulation of pri-miRNA transcription by RNA polymerase II; • positive regulation of production of miRNAs involved in gene silencing by miRNA; • پیرایش پسارونویسی; • GO:1901313 positive regulation of gene expression; • positive regulation of epithelial to mesenchymal transition; • positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis; • regulation of signaling receptor activity; • positive regulation of cell population proliferation; • negative regulation of gene expression; • negative regulation of pri-miRNA transcription by RNA polymerase II; • regulation of apoptotic process; • regulation of MAPK cascade; • cell development; • growth;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	652
	12159
	ENSG00000125378
	ENSMUSG00000021835
	P12644
	P21275
	NM_001202، NM_130850، NM_130851، XM_017021603، XM_017021604، XM_017021605 XM_005268015، NM_001202، NM_130850، NM_130851، XM_017021603، XM_017021604، XM_017021605
	NM_001316360 NM_007554، NM_001316360
	NP_570911، NP_001334841، NP_001334842، NP_001334843، NP_001334844، NP_001334845، NP_001334846، NP_570912 NP_001193، NP_570911، NP_001334841، NP_001334842، NP_001334843، NP_001334844، NP_001334845، NP_001334846، NP_570912
	NP_031580 NP_001303289، NP_031580
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین شمارهٔ ۴ ریخت‌زایی استخوان (انگلیسی: Bone morphogenetic protein 4) پروتئینی است که در انسان توسط ژن «BMP4» کُد می‌شود.^[۴]^[۵] این ژن بر روی بازوی بلند کروموزوم ۱۴ واقع است.

این مولکول حیاتی در مراحل اولیه رشد و تکامل جنینی در ناحیه چشم‌ها، قلب و کیسهٔ شنوایی وجود دارد.^[۶]

این پروتئین با بروز برخی از بیماری‌های استخوانی از جمله «فیبرودیسپلازی استخوانی‌شونده پیشرونده» در ارتباط است^[۷] و احتمالاً در بروز لب‌شکری هم نقش دارد.^[۸]

از دیگر نقش‌های مهم این پروتئین می‌توان به رشد و تکامل چشم‌ها و همچنین ریزش مو و کچلی اشاره کرد.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021835 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ van den Wijngaard A, Weghuis DO, Boersma CJ, van Zoelen EJ, Geurts van Kessel A, Olijve W (November 1995). "Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization". Genomics. 27 (3): 559–60. doi:10.1006/geno.1995.1096. PMID 7558046.
↑ Oida S, Iimura T, Maruoka Y, Takeda K, Sasaki S (November 1995). "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library". DNA Seq. 5 (5): 273–5. doi:10.3109/10425179509030980. PMID 7579580.
↑ Knöchel S, Dillinger K, Köster M, Knöchel W (November 2001). "Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes". Mech. Dev. 109 (1): 79–82. doi:10.1016/S0925-4773(01)00506-8. PMID 11677055.
↑ Kan L, Hu M, Gomes WA, Kessler JA (October 2004). "Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva (FOP)-Like Phenotype". Am. J. Pathol. 165 (4): 1107–15. doi:10.1016/S0002-9440(10)63372-X. PMC 1618644. PMID 15466378.
↑ Dixon MJ, Marazita ML, Beaty TH, Murray JC (March 2011). "Cleft lip and palate: understanding genetic and environmental influences". Nat. Rev. Genet. 12 (3): 167–78. doi:10.1038/nrg2933. PMC 3086810. PMID 21331089.

مشارکت‌کنندگان ویکی‌پدیا. «Bone morphogenetic protein 4». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۴ دسامبر ۲۰۱۷.

بیشتر بخوانید

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پیوند به بیرون

مکان ژن انسانی BMP4 در مرورگر ژنومی UCSC.
جزئیات ژن انسانی BMP4 در مرورگر ژنومی UCSC.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000021835 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7558046-4] van den Wijngaard A, Weghuis DO, Boersma CJ, van Zoelen EJ, Geurts van Kessel A, Olijve W (November 1995). "Fine mapping of the human bone morphogenetic protein-4 gene (BMP4) to chromosome 14q22-q23 by in situ hybridization". Genomics. 27 (3): 559–60. doi:10.1006/geno.1995.1096. PMID 7558046.

[pmid7579580-5] Oida S, Iimura T, Maruoka Y, Takeda K, Sasaki S (November 1995). "Cloning and sequence of bone morphogenetic protein 4 (BMP-4) from a human placental cDNA library". DNA Seq. 5 (5): 273–5. doi:10.3109/10425179509030980. PMID 7579580.

[pmid11677055-6] Knöchel S, Dillinger K, Köster M, Knöchel W (November 2001). "Structure and expression of Xenopus tropicalis BMP-2 and BMP-4 genes". Mech. Dev. 109 (1): 79–82. doi:10.1016/S0925-4773(01)00506-8. PMID 11677055.

[pmid15466378-7] Kan L, Hu M, Gomes WA, Kessler JA (October 2004). "Transgenic Mice Overexpressing BMP4 Develop a Fibrodysplasia Ossificans Progressiva (FOP)-Like Phenotype". Am. J. Pathol. 165 (4): 1107–15. doi:10.1016/S0002-9440(10)63372-X. PMC 1618644. PMID 15466378.

[pmid21331089-8] Dixon MJ, Marazita ML, Beaty TH, Murray JC (March 2011). "Cleft lip and palate: understanding genetic and environmental influences". Nat. Rev. Genet. 12 (3): 167–78. doi:10.1038/nrg2933. PMC 3086810. PMID 21331089.

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