نوروتوکسین مشتق از ائوزینوفیل

RNASE2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1GQV, 1HI2, 1HI3, 1HI4, 1HI5, 1K2A, 2BEX, 2BZZ, 2C01, 2C02, 2C05, 5E13
معین‌کننده‌ها
نام‌های دیگر	RNASE2, EDN, RAF3, RNS2, ribonuclease A family member 2
شناسه‌های بیرونی	OMIM: 131410 MGI: 1858598 HomoloGene: 121614 GeneCards: RNASE2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱۴ (موش)
پایان	51,400,475 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• nuclease activity; • endonuclease activity; • hydrolase activity; • ribonuclease A activity; • nucleic acid binding; • lipopolysaccharide binding; • ribonuclease activity; • lyase activity;
ترکیبات سلولی	• extracellular region; • کافنده‌تن; • extracellular exosome; • azurophil granule lumen;
فرایند زیستی	• کموتاکسی; • RNA catabolic process; • RNA phosphodiester bond hydrolysis, endonucleolytic; • positive regulation of protein targeting to mitochondrion; • neutrophil degranulation; • induction of bacterial agglutination; • GO:0051636 defense response to Gram-negative bacterium; • GO:0051637 defense response to Gram-positive bacterium; • RNA phosphodiester bond hydrolysis;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	6036
	54159
	ENSG00000169385
	ENSMUSG00000059606
	P10153
	O35292
	NM_002934
	NM_019398
	NP_002925
	NP_062271
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

نوروتوکسین مشتق از ائوزینوفیل (انگلیسی: Eosinophil-derived neurotoxin) یک آنزیم است که در انسان توسط ژن «RNASE2» کدگذاری می‌شود.^[۴]^[۵]^[۶]

این پروتئین در ائوزینوفیل‌ها یافت می‌شود.

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000059606 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.
↑ Rosenberg HF, Tenen DG, Ackerman SJ (Jul 1989). "Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family". Proc Natl Acad Sci U S A. 86 (12): 4460–4. doi:10.1073/pnas.86.12.4460. PMC 287289. PMID 2734298.
↑ "Entrez Gene: RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)".

مشارکت‌کنندگان ویکی‌پدیا. «Eosinophil-derived neurotoxin». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۴ فوریه ۲۰۱۹.

پیوند به بیرون

RNASE2 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا
Eosinophil-Derived Neurotoxin در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا

برای مطالعهٔ بیشتر

Rosenberg HF, Domachowske JB (2000). "Eosinophils, ribonucleases and host defense: solving the puzzle". Immunol. Res. 20 (3): 261–74. doi:10.1007/BF02790409. PMID 10741866.
Abu-Ghazaleh RI, Dunnette SL, Loegering DA, et al. (1993). "Eosinophil granule proteins in peripheral blood granulocytes". J. Leukoc. Biol. 52 (6): 611–8. PMID 1464733.
Sakakibara R, Hashida K, Kitahara T, Ishiguro M (1992). "Characterization of a unique nonsecretory ribonuclease from urine of pregnant women". J. Biochem. 111 (3): 325–30. PMID 1587793.
Hamann KJ, Ten RM, Loegering DA, et al. (1990). "Structure and chromosome localization of the human eosinophil-derived neurotoxin and eosinophil cationic protein genes: evidence for intronless coding sequences in the ribonuclease gene superfamily". Genomics. 7 (4): 535–46. doi:10.1016/0888-7543(90)90197-3. PMID 2387583.
Hamann KJ, Barker RL, Loegering DA, et al. (1990). "Sequence of human eosinophil-derived neurotoxin cDNA: identity of deduced amino acid sequence with human nonsecretory ribonucleases". Gene. 83 (1): 161–7. doi:10.1016/0378-1119(89)90414-9. PMID 2591744.
Barker RL, Loegering DA, Ten RM, et al. (1989). "Eosinophil cationic protein cDNA. Comparison with other toxic cationic proteins and ribonucleases". J. Immunol. 143 (3): 952–5. PMID 2745977.
Beintema JJ, Hofsteenge J, Iwama M, et al. (1988). "Amino acid sequence of the nonsecretory ribonuclease of human urine". Biochemistry. 27 (12): 4530–8. doi:10.1021/bi00412a046. PMID 3166997.
Sorrentino S, Tucker GK, Glitz DG (1988). "Purification and characterization of a ribonuclease from human liver". J. Biol. Chem. 263 (31): 16125–31. PMID 3182786.
Gleich GJ, Loegering DA, Bell MP, et al. (1986). "Biochemical and functional similarities between human eosinophil-derived neurotoxin and eosinophil cationic protein: homology with ribonuclease". Proc. Natl. Acad. Sci. U.S.A. 83 (10): 3146–50. doi:10.1073/pnas.83.10.3146. PMC 323469. PMID 3458170.
Niwata Y, Ohgi K, Sanda A, et al. (1985). "Purification and properties of bovine kidney ribonucleases". J. Biochem. 97 (3): 923–34. PMID 3926759.
de Beer T, Vliegenthart JF, Löffler A, Hofsteenge J (1995). "The hexopyranosyl residue that is C-glycosidically linked to the side chain of tryptophan-7 in human RNase Us is alpha-mannopyranose". Biochemistry. 34 (37): 11785–9. doi:10.1021/bi00037a016. PMID 7547911.
Hofsteenge J, Müller DR, de Beer T, et al. (1994). "New type of linkage between a carbohydrate and a protein: C-glycosylation of a specific tryptophan residue in human RNase Us". Biochemistry. 33 (46): 13524–30. doi:10.1021/bi00250a003. PMID 7947762.
Kardana A, Bagshawe KD, Coles B, et al. (1993). "Characterisation of UGP and its relationship with beta-core fragment". Br. J. Cancer. 67 (4): 686–92. doi:10.1038/bjc.1993.127. PMC 1968365. PMID 8471426.
Mosimann SC, Newton DL, Youle RJ, James MN (1996). "X-ray crystallographic structure of recombinant eosinophil-derived neurotoxin at 1.83 A resolution". J. Mol. Biol. 260 (4): 540–52. doi:10.1006/jmbi.1996.0420. PMID 8759319.
Krieg J, Hartmann S, Vicentini A, et al. (1998). "Recognition signal for C-mannosylation of Trp-7 in RNase 2 consists of sequence Trp-x-x-Trp". Mol. Biol. Cell. 9 (2): 301–9. doi:10.1091/mbc.9.2.301. PMC 25254. PMID 9450956.
Sur S, Glitz DG, Kita H, et al. (1998). "Localization of eosinophil-derived neurotoxin and eosinophil cationic protein in neutrophilic leukocytes". J. Leukoc. Biol. 63 (6): 715–22. PMID 9620664.
Zhang J, Rosenberg HF (2001). "Sequence variation at two eosinophil-associated ribonuclease loci in humans". Genetics. 156 (4): 1949–58. PMC 1461363. PMID 11102386.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000059606 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1577491-4] Mastrianni DM, Eddy RL, Rosenberg HF, Corrette SE, Shows TB, Tenen DG, Ackerman SJ (Jun 1992). "Localization of the human eosinophil Charcot-Leyden crystal protein (lysophospholipase) gene (CLC) to chromosome 19 and the human ribonuclease 2 (eosinophil-derived neurotoxin) and ribonuclease 3 (eosinophil cationic protein) genes (RNS2 and RNS3) to chromosome 14". Genomics. 13 (1): 240–2. doi:10.1016/0888-7543(92)90237-M. PMID 1577491.

[pmid2734298-5] Rosenberg HF, Tenen DG, Ackerman SJ (Jul 1989). "Molecular cloning of the human eosinophil-derived neurotoxin: a member of the ribonuclease gene family". Proc Natl Acad Sci U S A. 86 (12): 4460–4. doi:10.1073/pnas.86.12.4460. PMC 287289. PMID 2734298.

[entrez-6] "Entrez Gene: RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)".

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